Pifithrin-β hydrobromide

CAS No. 511296-88-1

Pifithrin-β hydrobromide( Cyclic Pifithrin-α hydrobromide | PFT-β hydrobromide )

Catalog No. M14763 CAS No. 511296-88-1

A cyclic analog of Pifithrin-α and a small molecule inhibitor of p53; prevents dexamethasone-induced cell death in murine thymocytes with EC50 of 2.01 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 31 In Stock
5MG 46 In Stock
10MG 77 In Stock
25MG 138 In Stock
50MG 201 In Stock
100MG 299 In Stock
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Biological Information

  • Product Name
    Pifithrin-β hydrobromide
  • Note
    Research use only, not for human use.
  • Brief Description
    A cyclic analog of Pifithrin-α and a small molecule inhibitor of p53; prevents dexamethasone-induced cell death in murine thymocytes with EC50 of 2.01 uM.
  • Description
    A cyclic analog of Pifithrin-α and a small molecule inhibitor of p53; prevents dexamethasone-induced cell death in murine thymocytes with EC50 of 2.01 uM, sensitizes p53-deficient tumors to radiotherapy and chemotherapy and increases apoptosis in cancer cells.
  • In Vitro
    Pifithrin-α hydrobromide (PFT β hydrobromide), an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β, the N-acetyl derivative. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects.
  • In Vivo
    ——
  • Synonyms
    Cyclic Pifithrin-α hydrobromide | PFT-β hydrobromide
  • Pathway
    Apoptosis
  • Target
    MDM2-p53
  • Recptor
    p53
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    511296-88-1
  • Formula Weight
    349.2886
  • Molecular Formula
    C16H17BrN2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 26 mg/mL
  • SMILES
    CC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2.Br
  • Chemical Name
    Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-, hydrobromide (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pietrancosta N, et al. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1561-4. 2. Barchéchath SD, et al. J Med Chem. 2005 Oct 6;48(20):6409-22. 3. Zuco V, et al. Neoplasia. 2008 Jun;10(6):587-96.
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